you can run isos off and any memory card the pad compatible with. ive used pro duo cf microdrive and sd. but if you are buying mainly for battery functions id pass because mines dont seem to work right. on 4AA 2600mah fully charged it will take a dead psp to 33 battery life(and it takes awhile to do that, i usually do it overnight). and it doesnt seem to charge psp and play at the same time, like its not supplying enough juice to simultaniously play and charge at the same time.